Selected Publications


Zou,M., Toivanen, R., Mitrofanova, A., Floc'h, N., Hayati, S., Sun, Y., Le Magnen, C., Chester, D., Mostaghel, E.A., Califano, A., Rubin, M.A., Shen, M.M., and Abate-Shen, C. (2017) Transdifferentiation as a Mechanism of Treatment Resistance in a Mouse Model of Castration-resistant Prostate Cancer. Cancer Disc. DOI: 10.1158/2159-8290.CD-16-1174. 

Owczarek, T., Kobayashi, T., Ramirez, R., Rong, L., Puzio-Kuter, A., Iyer, G., Teo, M., Sánchez-Vega, F., Wang, J., Schultz, N., Zheng, T., Solit, D., Al-Ahmadie, H., and Abate-Shen, C. (2017)  ARF Confers a Context-Dependent Response to Chemotherapy in Muscle-Invasive Bladder Cancer. Cancer Res; 77(4); 1035–46.

Dutta, A., Panja, S., Virk, R., Kim, J., Zott, R., Cremers, S., Golombos, D., Liu, D., Mosquera, J., Mostaghel, E.A., Barbieri, C., Mitrofanova, A., Abate-Shen, C.   Co-clinical Analysis of a Genetically Engineered Mouse Model and Human Prostate Cancer Reveals Significance of NKX3.1 Expression for Response to 5α-reductase Inhibition. European Urology.

Dutta A., Le Magnen C., Mitrofanova A., Ouyang X., Califano A., Abate-Shen C. (2016) Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science. 352(6293):1576-1580.

Mitrofanova A., Aytes A., Zou M., Shen M.M., *Abate-Shen C., and *Califano A. (2015). Predicting drug response in human prostate cancer from preclinical analysis of in vivo mouse models. Cell Rep. 12: 2060-2071. (*co-corresponding)

Aytes, A., Mitrofanova, A., Lefebvre, C., Alvarez, M.J., Castillo-Martin, M., Zheng, T., Eastham, J.A., Gopalan, A., Pienta, K.J., Shen, M.M., Califano, A., and Abate-Shen, C. (2014). Cross-species analysis of genome-wide regulatory networks identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy. Cancer Cell 25: 638-651.

Irshad, S., Bansal, M., Castillo-Martin, M. Aytes, A., Zheng, T., Wenske, S., Guarnieri, P., Sumazin, P., Le Magnen, C., Benson, M.C., Shen, M.M., Califano, A., and Abate-Shen, C. (2013). A molecular signature predictive of indolent prostate cancer. Sci. Transl. Med. 5:202ra122.

Aytes, A., Mitrofanova, A., Kinkade, C.W., Lefebvre, C., Lei, M., Phelan, V., Le, H.C., Koutcher, J.A., Cardiff, R.D., Califano, A., Shen, M.M., and Abate-Shen, C. (2013). ETV4 promotes metastasis in response to activation of P13 kinase and Ras signaling in a mouse model of advanced prostate cancer. Proc. Natl. Acad. Sci. USA 110:E3506-15.

Kobayashi, T., Wang, J., Al-Ahmadie, H.A., and Abate-Shen, C. (2013). ARF regulates the stability of p16 protein via REGy-dependent proteasome degradation. Mol Cancer Res. 11:828-33.

Delto, J.C., Kobayashi, T., Benson, M.C., McKiernan, J., and Abate-Shen, C. (2013). Preclinical analyses of intravesical chemotherapy for prevention of bladder cancer progression. Oncotarget 4:269-276.

Wang, Z.A., Mitrofanova, A., Bergen, S.K., Cardiff, R.D., Abate-Shen, C., Califano, A., and Shen, M.M. (2013). Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell of origin model for prostate cancer heterogeneity. Nat. Cell Biol. 15:274-283.

Wang, J., Kobayashi, T., Floc'h, N., Kinkade, C., Aytes, A., Dankort, D., Lefebvre, C., Mitrofanova, A., Cardiff, R., McMahon, M., Califano, A., Shen, M. and Abate-Shen, C. (2012). B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer. Cancer Res. 72:4765-4776.

Floc'h, N., Kinkade, C., Kobayashi, T., Aytes, A., Lefebvre, C., Mitrofanova, A., Cardiff, R., Califano, A., Shen, M., and Abate-Shen, C. (2012) Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model. Cancer Res. 72:4483-93.

Wang, J., Kumar, R., Biggs, V.J., Lee, H., Chen, Y., Kagey, M.H., Young, R.A., and Abate-Shen, C. (2011). The Msx1 homeoprotein recruits Polycomb to the nuclear periphery during development. Dev. Cell 21:575-588.

Seager, C., Puzio-Kuter, A.M., Patel, T., Jain, S., Cordon-Cardo, C., McKiernan, J., and Abate-Shen, C. (2009) Intravesical delivery of Rapamycin suppresses tumorigenesis in a mouse model of progressive bladder cancer. Cancer Prev. Res. 2:1008-1014.

Wang, X., Kruithof-de Julio, M., Economides, K.D., Walker, D., Yu, H., Halili, M.V., Hu, Y., Price, S., Abate-Shen, C., and Shen, M.M. (2009). A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature 461: 495-500.

Puzio-Kuter, A.M., Castillo-Martin, M., Kinkade C.W., Wang, X., Shen, T.H., Matos, T., Sun, Y., Shen, M.M., Cordon-Cardo, C., and Abate-Shen, C. (2009) Inactivation of p53 and Pten promotes invasive bladder. Genes Dev. 23:675-680.

Kinkade, C.W., Castillo-Martin, M., Puzio-Kuter, A., Yan, J., Foster, T.H., Gao, H., Sun, Y., Ouyang, X., Gerald, W.L., Cordon-Cardo, C., and Abate-Shen, C. (2008). Targeting Akt/TOR and Erk MAPK signaling inhibits hormone-refractory prostate cancer in a pre-clinical mouse model. J. Clin. Invest. 118:3051-3064.

Ouyang, X., Jessen, W.J., Al-Ahmadie, H., Serio, A.M., Lin, Y., Shih, W.J., Shen, M.M., Aronow, B.J., Vickers, A.J., Gerald, W., and Abate-Shen, C. (2008) Activator protein-1 transcription factors are associated with progression and recurrence of prostate cancer. Cancer Res. 68:2132-2144.

Banach-Petrosky, W., Jessen, W.J., Ouyang, X., Gao, H., Rao, J., Quinn, J., Aronow, B.J., and Abate-Shen, C. (2007) Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; Pten mutant mice. Cancer Res. 67:9089-9096.

Gao, H., Ouyang, X., Banach-Petrosky, W.A., Gerald, W.L., Shen, M.M., and Abate-Shen, C. (2006). Combinational activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer. Proc. Natl. Acad. Sci. USA 103:14477-14482.

Gao, H., Ouyang, X., Banach-Petrosky, W.A., Shen, M.M., and Abate-Shen, C. (2006). Emergence of androgen-independence at early stages of prostate cancer progression in Nkx3.1; Pten mice. Cancer Res. 66:7929-7933.

Abate-Shen, C., Banach-Petrosky, W.A., Sun, X., Economides, K.D., Desai, N., Gregg, J.P., Borowsky, A.D., Cardiff, R.D., and Shen, M.M. (2003). Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. Cancer Res. 63:3886-3890.

Kim, M., Cardiff, R., Desai, N., Banach-Petrosky, W.A., Parsons, R., Shen, M.M., and Abate-Shen, C. (2002). Cooperativity of Nkx3.1 and Pten loss-of-function in a mouse model of prostate carcinogenesis. Proc. Natl. Acad. Sci. USA 99:2884-2889.

Bhatia-Guar, R., Donjacour, A.A., Sciavolino, P. J., Kim, M., Desai, N., Young, P., Norton, C., Gridley, T., Cardiff, R.D., Cunha, G. R., Abate-Shen, C., and Shen, M.M. (1999). Roles for Nkx3.1 in prostate development and cancer. Genes Dev. 13: 966-977.

Review Articles

Le Magnen, C., Dutta, A., and Abate-Shen, C. (2016). Optimizing mouse models for precision cancer prevention. Nat. Rev. Cancer 16: 187-196.

Kobayashi, T., Owczarek, T.B., McKiernan, J.M., and Abate-Shen, C. (2015). Modeling bladder cancer in mice: opportunities and challenges. Nat. Rev. Cancer 15: 42-54.

Irshad, S. and Abate-Shen, C. (2013). Modeling prostate cancer in mice: Something old, something new, something premalignant, something metastatic. Cancer Metastases Rev. 32:109-22.

Seager, C., Puzio-Kuter, A.M., Cordon-Cardo, C., McKiernan, J., and Abate-Shen, C. (2010). Mouse models of human bladder cancer as a tool for drug discovery. Curr. Protoc. Pharmacol. 14.14.1-14.14.18.

Shen, M.M., and Abate-Shen, C. (2010). Molecular genetics of prostate cancer: new prospects for old challenges. Genes Dev. 24: 1967-2000.

Abate-Shen, C., Shen, M.M., and Gelmann, E. (2008). Integrating differentiation and cancer: the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis. Differentiation. 76: 717-727.

Shen, M.M. and Abate-Shen, C. (2007). Pten inactivation and the emergence of androgen-independent prostate cancer. Cancer Res. 67:6535-6538.

Abate-Shen, C. (2002). Deregulated homeobox gene expression in cancer: cause or consequence? Nat. Rev. Cancer 2: 777-785.

Abate-Shen, C., and Shen, M. M. (2000). Molecular genetics of prostate cancer. Genes Dev. 14: 2410-2434.